85-2053-28　Tubacin 2.5mg　CAS No:537049-40-4　167986

特徴

• Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50=4nm). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits a-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of a-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated a-tubulin deacetylation in mammalian cells.
• Synonyms:rel-N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
• Molecular Formula:C₄₁H₄₃N₃O₇S
• Molecular Weight:721.86
• Appearance:White to off-white powder
• Purity (HPLC):≥98%
• Melting Point:155-157°C
• Solubility:DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated)
• Storage:-20°C