85-2050-73　Zymostenol 5mg　CAS No:566-97-2　167133

特徴

• Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.1 It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ) with an EC50 value of 1uM in a RORγ coactivator recruitment assay in the presence of ursolic acid. It increases the number of myelin basic protein-positive oligodendrocytes generated from oligodendrocyte precursor cells in vitro.2 Zymostenol accumulates in cells following administration of microsomal antiestrogen-binding site (AEBS) ligands, such as tamoxifen, which are associated with cell differentiation and a protective type of autophagy.3,4 When used alone at a concentration of 20uM, zymostenol halts the cell cycle at the G0/G1 phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells.3
• Synonyms:5α-Cholest-8-en-3β-ol; 3β-Hydroxy-5α-cholest-8(9)-ene; Dihydrozymosterol; Δ8-Cholestenol; (3β,5α)-Cholest-8-en-3-ol
• Molecular Formula:C27H46O
• Molecular Weight:386.65
• Appearance:Crystalline solid
• Purity:≥95%
• Solubility:DMF, Ethanol
• Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with DMF or Ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.