85-2044-21　SAR131675 50mg　CAS No:1092538-80-1　166482

特徴

• SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD.
• Synonyms:2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide
• Molecular Formula:C₁₈H₂₂N₄O₄
• Molecular Weight:358.39
• Appearance:White to Pale Yellow Solid
• Melting Point:≥206°C (dec.)
• Solubility:DMSO (Slightly)
• Method for Determining Identity:Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
• TLC Conditions:SiO2; Dichloromethane: Methanol = 9:1; Visualized with UV and KMnO4; Single spot, Rf=0.45
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at 4°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.