85-2024-49　Ibrutinib, Free Base 50mg　CAS No:936563-96-1　164462

特徴

• Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM in cellular assay with Ramos cells. It demonstrated preference toward BTK over closely related kinases, blocked B cell function and BTK-dependent processes, and demonstrated clear efficacy in a mouse arthritis model. Young P.R., et al. "Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase." ChemMedChem. 2: 58-61 (2007).
• Appearance:White to off-white crystalline powder
• Purity:≥99% (HPLC)≥99% (TLC)
• Solubility:DMSO
• Melting Point:150-154°C

仕様

• Size：50mg
• Source Antigen：Synthetic
• Grade：Purified
• Purity：≥99% (HPLC), ≥99% (TLC)
• Form：White to off-white crystalline powder
• Molecular Formula：C25H24N6O2
• Molecular Weight Non Ab：440.5
• EU Commodity Code：38220090
• この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：936563-96-1

• 【試薬に関するお問合せ】
• アズワン株式会社 試薬・プロセス材料グループ
• TEL：06-6447-8641
• FAX：06-6447-8642
• E-mail：[email protected]