85-2010-96　CK 1827452 10mg　CAS No:873697-71-3　163151

特徴

• CK-1827452 is a diaryl urea compound that increases cardiac myosin ATPase activity in a dose-dependent manner that is selective for cardiac myosin over non-cardiac myosins. It promotes myosin cross-bridge formation, increasing the duration and amount of myocyte contraction without affecting intracellular calcium or cAMP. It has been shown to increase cardiac efficiency in clinical studies of patients with chronic heart failure.
• Synonyms:Methyl 4-[[2-Fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate; 4-[[2-Fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic Acid Methyl Ester; Omecamtiv Mecarbil
• Molecular Formula:C₂₀H₂₄FN₅O₃
• Molecular Weight:401.43
• Appearance:Supplied as a white solid
• Purity:≥97%
• Melting Point:187-190ºC
• Solubility:DMSO (Slightly), Methanol (Slightly)
• Method for Determining Identity:Proton NMR (CD3OD, DMSO-d6), 19F NMR (CD3OD, DMSO-d6) Spectroscopic and Mass Spectrometric analysis
• TLC Conditions:SiO2; Dichloromethane: Methanol = 9:1; Visualized with UV and KMnO4. Single Spot; Rf=0.5.
• Elemental Analysis:Calculated: %C: 59.84, %H: 6.03, %N: 17.45
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.