Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications. Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of molecular chaperones. Arimoclomol could treat a broad range of diseases. Arimoclomol activates the heat shock response. It is believed to act at Hsp70.
Melting Point:>131°C (dec.)
Solubility:DMSO (Slightly), Methanol (Slightly)
Atmosphere:Inert Gas
Method for Determining Identity:Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions:C18; Acetonitrile: Water: Ammonium Hydroxide=6:4:0.1; Visualized with UV and KMnO4; Single Spot, Rf=0.25
Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive.
