85-1958-83　MIC1, Recombinant, Human (Uncharacterized Protein C18orf8, Colon Cancer-associated Protein Mic1, Mic-1, C18orf8, FLJ23453) 20ug　149613

特徴

• GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114aa polypeptide chains.
• Source:Recombinant protein corresponding to human GDF-15/MIC-1, expressed in cell culture.
• Biological Activity:Biological activity was determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1-2ug/ml.
• Endotoxin:<0.1ng/ug (1EU/ug)
• AA Sequence:ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.