85-1794-35　SECTM1A, Fc Chimera, Recombinant, Mouse, aa28-165 (Secreted and Transmembrane 1A) 50ug　145831

特徴

• SECTM1A (secreted and transmembrane 1A), is 192 amino acid (aa) protein that shares ~45­51%, 81%, and 43% aa sequence identity with human SECTM1 (also called K12), rat SECTM1, and mouse SECTM1B/K12, respectively, and appears to share structural and functional characteristics with other SECTM1 proteins. Human SECTM1 can be found either found as an ~27kD intracellular type I transmembrane protein that shows a perinuclear, Golgi­like staining pattern, or as a 20kD soluble, secreted form, and is produced by some myeloid cells and by thymic epithelia and fibroblasts (1­3). Stimulation with IFN­gamma is often necessary to detect human SECTM1 expression, and it is thought to be an interferon early-response gene (1­5). Mouse SECTM1A cDNA encodes a signal sequence, an extracellular domain with four potential N­linked glycosylation sites, a transmembrane sequence, and a very short (~6aa) cytoplasmic sequence (6). SECTM1 proteins from human and mouse show species­specific binding of CD7 and co­stimulation of T cells, including enhancement of CD3­induced proliferation (2­4).
• Source:Recombinant protein corresponding to aa28-165 from mouse SECTM1A Fc Chimera, NS0-derived.
• Molecular Weight:~55-66kD
• Endotoxin:<0.01EU/1ug (LAL method)
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute in sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.