85-1793-10　SGC 0946 (1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-­bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro­xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro­pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea) 2mg　145692

特徴

• Potent DOT1L methyltransferase inhibitor (KD = 0.06nm, IC50 = 0.3nm in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8nm respectively). Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.
• Sequence:C28H40BrN7O4
• Solubility:DMSO (~100mM), Ethanol (~100mM)
• Molecular Weight:~618.57
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：2mg
• Grade：Highly Purified
• Purity：~99% (HPLC)
• Form：Supplied as a white solid.
• Molecular Formula：C28H40BrN7O4
• Molecular Weight Non Ab：618.57
• EU Commodity Code：38220090
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