85-1793-03　PF 04691502 (2-Amino-8-[trans-4-(2-hydroxyethoxy )cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-py rido[2,3-d]pyrimidin-7(8H)-one) 5mg　145688

特徴

• Potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16nm for human PI 3-K delta, alpha, gamma, beta, and mTOR, respectively). Displays no significant inhibitory activity at more than 80 protein kinases (concentration ≥ 10um) including hVps34, PI 3-K downstream kinases, and MAPK family members. Orally available. Induces robust cell cycle arrest at the G1 phase in U87MG cancer cells and antitumor activity in SKOV3 ovarian cancer xenograft models.
• Sequence:C22H27N5O4
• Solubility:DMSO (~100mM)
• Molecular Weight:~425.48
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：5mg
• Grade：Highly Purified
• Purity：~98% (HPLC)
• Form：Supplied as a green solid.
• Molecular Formula：C22H27N5O4
• Molecular Weight Non Ab：425.48
• EU Commodity Code：38220090
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