85-1793-01　PD 0332991 Isethionate (6-acetyl-8-cyclopentyl-5-methyl-2-[ [5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d] pyrimidin-7(8H)-one isethionate salt) 10mg　CAS No:827022-33-3　145686

特徴

• Potent Cdk4/6 inhibitor (IC50 values are 11 and 15nm for Cdk4 and Cdk6 respectively). Selective for Cdk4/6 over a panel of 34 additional protein kinases (IC50 values are > 10um). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines; blocks growth of intracranial glioblastoma multiforme xenografts in mice. Brain penetrant.
• Sequence:C24H29N7O2.C2H6O4S
• Solubility:DMSO (~10mM), H2O (~100mM)
• Molecular Weight:~573.66
• Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：~98% (HPLC)
• Form：Supplied as a yellow solid.
• Molecular Formula：C24H29N7O2.C2H6O4S
• Molecular Weight Non Ab：573.66
• EU Commodity Code：38220090
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• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：827022-33-3

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