85-1792-92　JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3,2'-[1,3]dioxane­-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione) 10mg　CAS No:442644-28-2　145679

特徴

• Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17um); targets the beta-catenin destruction complex (GSK-3beta/AXIN/APC) to induce beta-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-kappaB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8um).
• Sequence:C21H18N2O6
• Solubility:DMSO (~100mM)
• Molecular Weight:~394.38
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：~97% (HPLC)
• Form：Supplied as a solid.
• Molecular Formula：C21H18N2O6
• Molecular Weight Non Ab：394.38
• EU Commodity Code：38220090
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• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：442644-28-2

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