85-1792-74　［受注停止］BMS 303141 (ATP Citrate Lyase Inhibitor, Orally Bioavailable, 3,5-Dichloro-2-hydroxy-N-(4-methoxy­[1,1'-biphenyl]-3-yl)-benzenesulfonamide) 10mg　CAS No:943962-47-8　145663

特徴

• ATP citrate lyase (ACL) inhibitor (IC50 = 0.13um for human recombinant ACL); blocks lipid synthesis (IC50 = 8um in HepG2 cells). Displays no cytotoxicity up to a concentration of 50um. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.
• Sequence:C19H15Cl2NO4S
• Solubility:DMSO (~10mM), Ethanol (~50mM)
• Molecular Weight:~424.3
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：~99% (HPLC)
• Form：Supplied as a white crystalline solid.
• Molecular Formula：C19H15Cl2NO4S
• Molecular Weight Non Ab：424.3
• EU Commodity Code：38220090
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• CAS No ：943962-47-8

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