85-1792-70　10Z-Hymenialdisine 500ug　CAS No:82005-12-7　145659

特徴

• Pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively.) Inhibits NF-κB activation and blocks IL-8 production in U937 cells (IC50 values are 1-2 and 0.34-0.48uM respectively).
• Synonyms:(4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one, SK&F 108752
• Molecular Weight:324.13
• Molecular Formula:C11H10BrN5O2
• Solubility:DMSO to 10mM
• Method for Determining Identity:Proton NMR
• Appearance:Supplied as a yellow solid.
• Purity:~97% (HPLC)
• Storage and Stability:Store at -20°C under inert atmosphere. This product is light sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.