85-1791-24　Leptin receptor BioAssay™ ELISA Kit, Mouse 96Tests　143951

特徴

• Sandwich ELISA quantitative detection kit for Mouse Leptin receptor in cell culture supernates, serum and plasma (heparin, EDTA).
• Leptin receptor (or Obese receptor, OBR) is a single membrane-spanning receptor most related to the gp130 signal-transducing component of the IL-6 receptor, the G-CSF receptor, and the LIF receptor. OB-R mRNA is expressed not only in choroid plexus, but also in several other tissues, including hypothalamus.1 Leptin acts through the leptin receptor, a single-transmembrane domain receptor of the cytokine-receptor family.2 Leptin controls energy balance and food intake through the leptin receptor in the hypothalamus of the brain, which suggests that some polymorphisms of the leptin receptor gene (LEPR) might contribute to obesity or obesity-related diseases.3 Leptin is also involved in the regulation of blood pressure through the leptin receptor.4
• Assay Range:156pg/ml-10,000pg/ml
• Sensitivity:< 5 pg/ml
• Crossreactivity:There is no detectable cross-reactivity with other relevant proteins.
• Uniprot ID:P48356
• Entrez Gene ID:16847
• Kit Components:96-well plate pre-coated with anti-Leptin receptor, MouseLyophilized recombinant Leptin receptor, Mouse standard, 10ng/tube, 2EaUSB Cat No Kit Component143696 Avidin-Biotin-Peroxidase Complex (ABC), 130ul (1:100 dilution)143697 Sample diluent buffer, 30ml143698 Antibody diluent buffer, 12ml143699 ABC diluent buffer, 12ml143700 TMB color developing agent, 10ml143701 TMB stop solution, 10ml
• Storage and Handling:Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.