85-1788-57　BMP-4, Recombinant, Mouse (BMP-2, BDVR4) 2ug　143295

特徴

• Bone morphogenetic proteins(BMPs) constitute a subfamily within the TGF-beta superfamily of structurallyrelated signaling proteins. Members of this superfamily are widely distributedthroughout the body and are involved in diverse physiological processes duringboth pre- and postnatal life. Like BMP-7, BMP-4 is involved in the developmentand maintenance of bone and cartilage. Reduced expression of BMP-4 isassociated with a number of bone diseases, including the heritable disorderFibrodysplasia Ossificans Progressiva. E.coli derived murine BMP-4 is a fully active homodimeric proteinconsisting of two 106 amino acid subunits which correspond to amino acids303-408 of the full length BMP-4 precursor.
• Biological Activity:Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-15ng/ml.
• AA Sequence:KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
• Quality Control:Verified by N-terminal and Mass Spectrometry analyses (when applicable).
• Protein Content:Verified by UV Spectroscopy and/or SDS-PAGE gel.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with citric acid. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA). Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Additional freeze/thaw cycles may cause some denaturation of the protein.