Phosphodiesterase 1C is a cAMP/cGMP dual-specific, calcium/calmodullin-dependent phosphodiesterase. PDE1C has been shown to affect vascular smooth muscle proliferation and atherosclerosis, insulin secretion regulation, spermatozoa development, and erectile dysfunction. At least five PDE1C isoforms have been reported, the expression of which are regulated in a tissue/cell-specific manner.
Source:Recombinant corresponding to aa2-634 from human PDE1C, fused to GST-tag at N-terminal, expressed in a Baculovirus-infected Sf9 cell expression system.
Molecular Weight:~98kD
Applications:Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Specific Activity:~8180pmol/min/ug
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：10ug
Source Antigen：Recombinant, Sf9 insect cells
Grade：Purified
Purity：Purified (~50%)
Form：Supplied as a liquid in 45mM Tris-HCl, pH 8.0, 124mM sodium chloride, 2.4mM potassium chloride, 20mM glutathione, 3mM DTT, 10% glycerol.
