MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. It is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. It plays a role in the cell cycle.
Source:Recombinant corresponding to aa30-397 from mouse MAP3K8, fused to His-GST-tag at N-terminal, expressed in a Baculovirus-infected Sf9 cell expression system.
Molecular Weight:~70kD
Specific Activity:~8.5pmole/min/mg
Applications:Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：10ug
Source Antigen：Recombinant, Sf9 insect cells
Grade：Purified
Purity：Purified (~38%)
Form：Supplied as a liquid in 40mM Tris-HCl, pH 8.0, 110mM sodium chloride, 2.4mM potassium chloride, 5mM glutathione, 134mM imidazole, 3mM DTT, 20% glycerol.
