Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. Research on molecular level discovered that neuregulin recombinant could make disturbed myocardial cell structure into order and strengthen the connection between myocardial cells by intercalated discs re-organization. Pharmacodynamic experiments in animals showed that neuregulin (NRG1) recombinant can reduce the degree of damage on myocardial cells caused by ischemia, hypoxia and viral infection.
Source:Recombinant corresponding to human Heregulin-B2, expressed in E.coli.
Molecular Weight:~7kD
Biological Activity:The ED50, calculated by the dose-dependant stimulation of human MCF-7 cells is <0.5ng/ml, corresponding to a specific activity of >2x10e6units/mg.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：10ug
Source Antigen：Recombinant, E.coli
Grade：Highly Purified
Purity：~95% (RP-HPLC and SDS-PAGE)
Form：Supplied as a lyophilized powder from 20mM PB, pH 7.0, 0.5%HSA, 2% mannitol. Reconstitute with sterile 18Mo-cm H2O to 100ug/ml.
