85-1779-33　Wortmannin 1mg　CAS No:19545-26-7　045393

特徴

• Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor.
• Synonyms:KY 12420; BRN 0067676; NSC 627609; Antibiotic SL-2052
• Source:Penicillium sp.
• Molecular Weight:428.4
• Molecular Formula:C23H24O8
• Solubility:DMSO, methanol, ethanol or chloroform. Slightly soluble in water.
• Appearance:Supplied as a white to off-white solid.
• Purity:≥98% (HPLC)
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.