85-1779-21　Trichostatin A (TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide) 5mg　CAS No:58880-19-6　045374

特徴

• Antibiotic. Antifungal. Antiprotozoal. Potent and reversible, cell permeable inhibitor of histone deacetylase (HDAC). Immunosuppressive. Anticancer compound. Antifibrogenic. Apoptosis inducer. Induces cell growth arrest at both G1 and G2/M phases. Enhances the efficacy of anticancer agents that target DNA. Inactivates mitotic spindle checkpoint. Smooth muscle cell proliferation inhibitor. Telomerase inhibitor. Downregulates DNA methyltransferase DNMT1 and affects DNA methylation. Anti-inflammatory. Inhibits osteoclastogenesis and bone resorption.
• Synonyms:TSA; A300; R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide
• Source:Isolated from Streptomyces hygroscopicus
• Molecular Formula:C17H22N2O3
• Molecular Weight:302.4
• Solubility:DMSO, ethanol, methanol, dimethyl formamide, acetonitrile or chloroform. Insoluble in water or hexane.
• Appearance:Supplied as an off-white solid.
• Purity:≥95% (HPLC)
• Storage and Stability:Store at -20°C. After reconstitution, prepare aliquots and store at -20°C. Stable for 1 year after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.