TRAIL-R2 (DR5; CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
Binds to human and mouse TRAIL.
Sequence:The extracellular domain, aa52-212, of human TRAIL-R2, fused to the Fc portion of human IgG1, expressed in HEK 293 cells.
Molecular Weight:~50kD (SDS-PAGE)
Biological Activity:Blocks human or mouse TRAIL activity in a concentration of 1-10ug/ml.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
