85-1779-05　Thiocolchicoside 25mg　045336

特徴

• Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products. Apoptosis inducer
• Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway. Therapeutic option for the management of bone metastatic disease.
• Synonyms:BRN 0072205; NSC 147755; Coltramyl; 10-thio-Colchicoside; 2-Demethoxy-2-glucosidoxythiocolchicine
• Source:Semi-synthetic
• Molecular Weight:563.6
• Molecular Formula:C27H33NO10S
• Solubility:Water or ethanol.
• Appearance:Supplied as a yellow solid.
• Purity:≥95% (NMR)
• Storage and Stability:Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.