85-1778-89　Streptozotocin 250mg　CAS No:18883-66-4　045318

特徴

• Antibiotic Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic beta-cells Mutagenic. Potent alkylating agent. Potent DNA methylating agent Nitric oxide (NO) donor. Vasorelaxant. Cytotoxic to cells that express GLUT2 glucose transporter. O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) inhibitor. Genotoxic. Induces DNA damage. Produces DNA strand breaks. Cell death inducer. Antineoplastic. Anti-cancer agent used in chemotherapy. Induces cell cylce arrest at G2.
• Synonyms:2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; Streptozocin; STZ; NSC 85998; Antibiotic U9889; Zanosar
• Molecular Weight:265.2
• Molecular Formula:C₈H₁₅N₃O₇
• Solubility:Water or ethanol.
• Method for Determining Identity:UV and IR
• Appearance:Supplied as an off-white to pale yellow powder.
• Purity:≥98% (HPLC)≥75% (α anomer)
• Note:Once the compound is in solution it spontaneously releases NO gas at room temperature. We recommend to prepare fresh solutions immediately before use.
• Storage and Stability:Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.