85-1778-83　Splitomicin (Splitomycin, 1,2-Dihydro-3H-naphthopyran-3-one, 1-Naphthalen propanoic acid) 5mg　045308

特徴

• Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.
• Synonyms:Splitomycin; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1-Naphthalen propanoic acid
• Molecular Weight:198.2
• Molecular Formula:C13H10O2
• Solubility:Methanol, ethanol or DMSO.
• Method for Determining Identity:Proton NMR
• Appearance:Supplied as a white to off-white solid.
• Purity:≥98% (NMR)
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.