Sirtuins (Silent information regulators; SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical regulators of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. SIRT1 has been suggested as potential biomarker for tumorigenesis.
Storage and Stability:Short-term Storage: +4°CLong-term Storage: +4°C
仕様
Size：96Tests
Source Antigen：Human
Specificity：Detects human sirtuin1. Does not cross-react with human sirtuin2, human sirtuin5, human sirtuin5 (intact form) or human sirtuin6.
