85-1778-21　Radicicol 5mg　CAS No:12772-57-5　045192

特徴

• Antibiotic. Protein tyrosine kinase inhibitor. Has antifungal, antimalarial, antiangiogenic (in vivo), anti-inflammatory and antiviral activity. Cyclooxygenase-2 (COX-2) expression inhibitor without affecting COX-1 expression in LPS-stimulated macrophages. Induces the differentiation of HL-60 cells into macrophages. Potent HSP90 inhibitor. Anticancer compound. In vivo Rad/Raf interaction inhibitor. Inhibitor of AP-1-, NF-kappaB- and serum response factor (SRF)-mediated transcription. Suppresses expression of iNOS (NOS II). Non-competitive inhibitor of ATP citrate lyase. DNA topoisomerase VI and type II DNA topoisomerase inhibitor. Protects against LPS/IFN-gamma-induced neuronal cell death. Apoptosis inducer.
• Synonyms:Monorden; NSC 294404; RHI-12648
• Source:Gilmaniella sp.
• Molecular Weight:364.8
• Molecular Formula:C18H17ClO6
• Solubility:DMSO, methanol, acetone, ethyl acetate or chloroform
• Appearance:Supplied as a white to slightly yellow solid.
• Purity:≥99% (HPLC)
• Storage and Stability:Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.