85-1778-13　(R,R)-Hymeglusin (1233A, F-244, L-659-699) 500ug　CAS No:29066-42-0　045186

特徴

• beta-Lactone antibiotic. Antibacterial and antifungal. Specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the enzyme. Mevalonate biosynthesis inhibitor.
• Source:Isolated from fungal strain Scopulariopsis sp. F-244.
• Synonyms:(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic Acid; (+)-F-(244); Antibiotic 1233A; Antibiotic F 244; F 244; Hymeglusin; L 659699; [2R-[2α(2E,4E,7R*),3β]]-11-[3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic Acid
• Molecular Weight:324.4
• Molecular Formula:C₁₈H₂₈O₅
• Appearance:White to off-white solid
• Purity:≥95% (HPLC)
• Solubility:Soluble in methanol, ethanol, DMSO, chloroform or ethyl acetate. Insoluble in water or hexane.
• Storage and Stability:Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.