85-1777-73　Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) 1mg　CAS No:16561-29-8　045147

特徴

• Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin.
• Synonyms:PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate
• Molecular Formula:C36H56O8
• Molecular Weight:616.83
• Purity:≥98% (HPLC)
• Appearance:Supplied as a white to off-white solid
• Solubility:Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
• Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide.. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.