OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
Biological Activity:Blocks T cell proliferation induced by CD134L.
Sequence:Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1.
Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CStable for at least 6 months after receipt when stored at -20°C.
仕様
Size：50ug
Source Antigen：Recombinant, Human, HEK 293 cells
Grade：Highly Purified
Purity：≥95% (SDS-PAGE)
Form：Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
