85-1777-49　Orlistat 50mg　CAS No:96829-58-2　045122

特徴

• Hypolipemic cell permeable and irreversible pancreatic, gastric and carboxylester lipase inhibitor. Anti-obesity and antihypercholesterolemic compound. Antitumor compound by inhibition of the thioesterase domain of fatty acid synthase (FASN). Anti-proliferative. Causes cell cycle arrest at G1 phase. Apoptosis inducer through caspase-3 activation. Sn-1-selective-diacylglycerol lipases alpha (DAGLalpha) inhibitor. Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways.
• Source:Synthetic. Originally isolated from Streptomyces sp.
• Synonyms:Tetrahydrolipstatin; Xenical; Alli; Ro-18-0647
• Molecular Weight:495.7
• Molecular Formula:C29H53NO5
• Appearance:Supplied as a white to off-white solid.
• Purity:≥98% (HPLC)
• Solubility:DMSO, Ethanol, DMF
• Method for Determining Identity:HPLC and IR
• Storage and Stability:May be stored at 4°C for short-term only. Stable for 12 months after receipt when stored at -20°C. Protect from light and moisture. For maximum recovery of product, centrifuge the original vial prior to removing the cap.