Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.
Solubility:DMSO (≤5mg/ml), ethyl acetate or 100% ethanol (1.2mg/ml); insoluble in water
Appearance:Supplied as a white to pale yellow solid.
Purity:≥98% (NMR)
Storage and Stability:For short term, store at 4°C. For long term, store at -20°C in the dark. Solutions may decompose slowly. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
