Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis.
Biological Activity:Induces axon outgrowth.
Sequence:Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.
Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CStable for at least 6 months after receipt when stored at -20°C.
仕様
Size：10ug
Source Antigen：Recombinant, Human, HEK 293 cells
Grade：Highly Purified
Purity：>95% (SDS-PAGE)
Form：Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2, with trehalose and Brij35.
