Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Biological Activity:Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
Sequence:The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).
Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CStable for at least 6 months after receipt when stored at +4°C.
仕様
Size：50ug
Source Antigen：Recombinant, Mouse, CHO cells
Grade：Highly Purified
Purity：>95% (SDS-PAGE)
Form：In PBS.
Specificity：Binds to human and mouse MHC class II.
