Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
Sequence:Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.
Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CWorking aliquots are stable for up to 3 months when stored at -20°C.
仕様
Size：10ug
Source Antigen：Recombinant, Human, HEK 293 cells
Grade：Purified
Purity：>90% (SDS-PAGE)
Form：Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
