85-1776-47　IWR-1 (IWR-1-endo) 25mg　CAS No:1127442-82-3　044963

特徴

• Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay).
• Synonyms:rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
• Molecular Formula:C₂₅H₁₉N₃O₃
• Molecular Weight:409.4
• Purity:≥98%
• Appearance:White to off-white solid.
• Solubility:Soluble in DMSO or DMF. Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, dissolve first in DMSO and then dilute with the aqueous buffer of choice. Solubility in a 1:3 solution of DMSO:PBS (pH 7.2) (~0.25mg/ml). It is recommended to use fresh aqueous solutions and not to store them for more than one day.
• Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CStable for at least 2 years after receipt when stored at -20°C.