85-1776-45　Irisin,Fc, Recombinant, Human (Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5) 10ug　044962

特徴

• Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
• AA Sequence:aa16-127 of human Irisin fused at the C-terminus to the Fc portion of human IgG1.
• Species Homology:aa16-127 of human Irisin corresponds to aa29-140 of mouse Irisin. Irisin has 100% identity betwen mouse, rat, monkey and human.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Further dilutions can be made in PBS, >0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.