Cytoplasmic microtubule inhibitor. Cell permeable, antimicrobial, anti-inflammatory, antimitotic and cytotoxic compound. Induces a complete and reversible breakdown/disruption of Golgi membranes into smaller vesicular structures. Blocks the association of the ADP-ribosylation factor and beta-COP to the Golgi membrane. Blocks protein transport to the plasma membrane and inhibits gap junctional communication. HIV-1 inhibitor. Blocks the cytotoxicity of ricin and diphtheria toxin. S-Adenosylhomocysteinase hydrolase inhibitor and cellular methylations inhibitor. DNA polymerase beta lyase activity inhibitor. Anti-cancer compound.
Source:Isolated from Anthelia sp.
Synonyms:3-[(Decahydro-1α,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone; IQ
Molecular Weight:358.5
Molecular Formula:C22H30O4
Solubility:Methanol, ethanol, DMSO or hexane
Appearance:Supplied as a yellow solid.
Method for Determining Identity:Proton NMR and MS
Purity:≥98% (HPLC)
Storage and Stability:May be stored at 4°C for short-term only. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
