IL-37 (IL-1F7) belongs to the IL-1 family. It binds to interleukin-18 receptor (IL-18R) but not to IL-1 receptor. It was shown to play an important role as a link between innate and adaptive immunity and it is suggested as a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis. It was also shown to inhibit tumor growth.
Recombinant protein corresponding to aa1-218 of human IL-37, fused to His-Tag at C-terminus, expressed in E. coli.
Molecular Weight:~30kD (SDS-PAGE)
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
