85-1776-01　［取扱停止］Heptelidic acid 1mg　CAS No:57710-57-3 (74310-84-2 deleted)　044883

特徴

• Antibiotic. Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GADPH. Anticancer compound. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Antimalarial. Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols.
• Source:Isolated from Trichoderma sp.
• Synonyms:Koningic acid; Avocettin; FO-4443; BRN 5091359
• Molecular Weight:280.3
• Molecular Formula:C15H20O5
• Solubility:DMSO (10mg/ml), ethanol (1mg/ml), methanol (1mg/ml) or water (1mg/ml).
• Appearance:Supplied as a white solid.
• Purity:≥95% (HPLC)
• Storage and Stability:May be stored at 4°C for short-term only. Keep cool and dry. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.