FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Biological Activity:Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
Sequence:Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to the Fc portion of human IgG1.
Molecular Weight:~60kD (SDS-PAGE, full-length) FGF23 is cleaved between arg179 and ser 180 (~40kD).
Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CWorking aliquots are stable for up to 3 months when stored at -20°C.
仕様
Size：10ug
Source Antigen：Recombinant, Human, HEK 293 cells
Grade：Highly Purified
Purity：>90% (SDS-PAGE)
Form：Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
