85-1775-35　Ds(+)-threo-Isocitric acid trisodium salt 100mg　CAS No:903507-52-8　044766

特徴

• Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation.
• Synonyms:(1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid trisodium salt
• Molecular Formula:C6H5O7•3Na
• Molecular Weight:258.1
• Appearance:Supplied as a white solid.
• Purity:≥98% (NMR)
• Solubility:Soluble in water
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Light sensitive. Store solutions at -20°C in the dark.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.