The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
Biological Activity:Inhibits adipogenesis of 3T3L-1 cells and mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
Sequence:Signal peptide and extracellular domain of human DLL4 (aa 1-529) are fused at the C-terminus to the Fc portion of human IgG1.
Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CWorking aliquots are stable for up to 3 months when stored at -20°C.
仕様
Size：10ug
Source Antigen：Recombinant, Human, HEK 293 cells
Grade：Highly Purified
Purity：>95% (SDS-PAGE)
Form：Supplied as a lyophilized powder in PBS, pH 7.2, 0.5% Trehalose.
