Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic. Potential anti-Alzheimer agent.
Synonyms:DBH; DBHA-SKF; SKF 108753
Source:Isolated from sponge Axinella carteri.
Molecular Weight:245.2
Molecular Formula:C11H11N5O2
Solubility:DMSO, ethanol or methanol
Method for Determining Identity:Proton NMR and MS.
Appearance:Supplied as a yellow solid.
Purity:≥95% (HPLC)
Storage and Stability:Store at -20°C under inert atmosphere. Keep cool and dry. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
