85-1774-89　Citrinin 5mg　CAS No:518-75-2　044666

特徴

• Antibiotic. Antiprotozoal. Antimicrobial. Cytotoxic and genotoxic in various mammalian cells. Mitochondrial permeability transition pore (MPTP) activator. Apoptosis inducer. ERK and JNK signaling pathways activator. Nephrotoxic mycotoxin. Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways. Tubulin polymerization and mitotic spindle assembly inhibitor. Increases reactive oxygen species (ROS). Induces cell cycle arrest at the G0/G1 and G2/M phase.
• Synonyms:NSC 186; BRN 0088597; Antimycin, 4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
• Source:Penicillium citrinum strain FKI-4836
• Molecular Weight:250.3
• Molecular Formula:C13H14O5
• Solubility:Methanol, ethanol, methylene chloride, pyridine or dioxane. Insoluble in water, chloroform or hexane. Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
• Appearance:Supplied as a yellow solid.
• Purity:≥97% (HPLC)
• Storage and Stability:Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.