85-1774-10　Atpenin A5 250ug　CAS No:119509-24-9　044573

特徴

• Antibiotic. Antifungal. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor. Mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator. Cardioprotective. Modulates mitochondrial ROS generation during cardioprotection.
• The IC50 value against bovine heart complex II is 3.6nM (which is ~300-fold lower than the IC50 value of carboxin (1.1uM)). It also inhibits fumarate reductase of Ascaris suum (IC50 = 12nM). Inhibition of E. coli succinate dehydrogenase is less potent (IC50 = 5uM). By co-crystallization studies of atpenin A5 and complex II, the binding site of atpenin A5 was found to be the quinone-binding site of complex II. Additionally, atpenin A5 has been shown to have a protective action against ischemia-reperfusion via the activation of mitochondrial KATP channels.
• Synonyms:3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone
• Source:Synthetic. Originally isolated from Penicillium sp. strain FO-125.
• Molecular Weight:366.2
• Molecular Formula:C15H21Cl2NO5
• Solubility:Acetone, acetonitrile, chloroform, ethyl acetate, DMSO, methanol or ethanol. Insoluble in water or hexane.
• Appearance:Supplied as a white to off-white solid.
• Purity:≥95% (HPLC)
• Storage and Stability:Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.