85-1773-41　［受注停止］10Z-Hymenialdisine 500ug　CAS No:82005-12-7　044433

特徴

• Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor.
• Synonyms:Hymenialdisine; 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
• Source:Axinella carteri
• Molecular Weight:324.1
• Molecular Formula:C₁₁H₁₀BrN₅O₂
• Method for Determining Identity:Proton NMR
• Solubility:DMSO
• Appearance:Supplied as a solid.
• Purity:≥97% (HPLC) (Contains traces of the 10E-isomer)
• Storage and Stability:Store at -20°C under inert atmosphere. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.