Virginiamycin complex is defined as a mixture of 75% virginamycin M1 (ostreogrycin A) and 25% virginiamycin S1 and the less abundant S analogs. As the two major components have quite different solubilities these proportions are not readily achieved or used. The individual components are isolated and re-combined to provide the defined components of virginiamycin complex. The structure composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase center of the 50S ribosome induced by ostreogrycin A.
Description:Virginiamycin Complex
Molecular Weight:525.6 (Virginiamycin M1) and 823.9 (Virginiamycin S1)
Solubility:Soluble in DMF or DMSO. Viriginiamycin M1 has only limited solubility in ethanol and methanol. Poor water solubility.
Storage and Stability:Lyophilized powder may be stored at -20°C and is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：5mg
Source Antigen：Streptomyces sp.
Grade：Highly Purified
Purity：≥95% by HPLC (75% Virginamycin M1, 20% Virginiamycin S1, ~1% other minoranalogs)
