Platencin is a more potent analogue of Platensimycin also discovered from a strain of Streptomyces platensis. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, β-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.
Source:Platencin
Molecular Weight:~425.2
Solubility:Soluble in ethanol, methanol, DMF or DMSO.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
