Moxidectin is a semi-synthetic milbemycin derived from nemadectin by selective oxidation followed by methyloximation. Moxidectin was patented in 1991 as an anthelmintic for internal parasite control. The presence of the methyloxime affords moxidectin a greater hydrophobicity and longer biological half-life compared to nemadectin. It binds selectively to parasiteglutamate-gatedchloride neurotransmission leading to ion channels and disrupts paralysis and death of the parasite.
Source:Semi-synthetic Moxidectin
Molecular Weight:~639.8
Solubility:Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
